Etik açıdan üç ebeveynli bebek

Vasif Mammadov, Zafer ARAS

Öz


Özet
Çok ebeveynli çocuk olmak son zamanlarda dini, ahlaki, etik tartışmalara konu olan, hakkında birçok ülkede yasal düzenlemelerin olmadığı ve toplumlarda tartışılan bir konudur. Bu çalışmada, öncelikle güncel literatür gözden geçirilmiş, ardından mitokondriyal donasyon tekniklerinden (pronükleer transfer, stoplazmik transfer, spindle nükleer transfer) bahsedilerek konunun etik boyutu irdelenmiştir. Mitokondri bağışı tekniklerinin klinik uygulamaları ve etik açıdan değerlendirilmesini kolaylaştırmak adına iki örnek vaka da sunulmuştur.

Anahtar kelimeler: Üç ebeveynli bebek, mitokondriyal hastalıklar, mitokondri bağışı, genetik müdahale

Tam Metin:

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Referanslar


Kaynaklar:

Giles RE, Blanc H, Cann HM, Wallace DC (November 1980). "Maternal inheritance of human mitochondrial DNA". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6715–9. doi:10.1073/pnas.77.11.6715. PMC 350359 . PMID 6256757.

Ember, Melvin; Ember, Carol R., eds. (2004). Encyclopedia of Medical Anthropology: Health and Illness in the World's Cultures. 1. Cultures. New York: Kluwer Academic/Plenum Publishers. ISBN 0-306-47754-8

Lyndsey Craven,1 Helen A Tuppen,1 Gareth D Greggains,2,3 Stephen J Harbottle,2 Julie L Murphy,1 Lynsey M Cree,1Alison P Murdoch,2,4 Patrick F Chinnery,1 Robert W Taylor,1 Robert N Lightowlers,1 Mary Herbert,2,3,4 and Douglass M Turnbull1,4,5Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA diseaseNature. 2010 May 6; 465(7294): 82–85.

M. Yamada et al. Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes. Cell Stem Cell. Published online May 19, 2016. doi: 10.1016/j.stem.2016.04.001.

L.A. Hyslop et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature. Published online June 8, 2016. doi: 10.1038/nature18303.

Cree, L; Loi, P (January 2015). "Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool-technicalities and possible risks.". Molecular human reproduction. 21 (1): 3–10. doi:10.1093/molehr/gau082. PMID 25425606.

Barritt J1, Willadsen S, Brenner C, Cohen J. Cytoplasmic transfer in assisted reproduction.Hum Reprod Update. 2001 Jul-Aug;7(4):428-35.

Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases; Board on Health Sciences Policy; Institute of Medicine (2016). Claiborne, Anne; English, Rebecca; Kahn, Jeffrey, eds. Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations. National Academies Press. ISBN 978-0-309-38870-2

Sara Reardon. ‘Three-parent baby’ claim raises hopes — and ethical concerns. Nature doi:10.1038/nature.2016.20698

J. Zhang, H. Liu, S. Luo, A. Chavez-Badiola, Z. Liu, m. yang, S. Munne, M. Konstantinidis, D. Wells, T. Huang First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome DOI: http://dx.doi.org/10.1016/j.fertnstert.2016.08.004

Peter Dockrill. World-first in Ukraine as 'three-parent' baby born to an infertile couple http://www.sciencealert.com/world-first-in-ukraine-as-three-parent-baby-born-to-an-infertile-couple


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