Etik açıdan üç ebeveynli bebek

Vasif Mammadov, Zafer ARAS

Öz


Özet
Çok ebeveynli çocuk olmak son zamanlarda dini, ahlaki, etik tartışmalara konu olan, hakkında birçok ülkede yasal düzenlemelerin olmadığı ve toplumlarda tartışılan bir konudur. Bu çalışmada, öncelikle güncel literatür gözden geçirilmiş, ardından mitokondriyal donasyon tekniklerinden (pronükleer transfer, stoplazmik transfer, spindle nükleer transfer) bahsedilerek konunun etik boyutu irdelenmiştir. Mitokondri bağışı tekniklerinin klinik uygulamaları ve etik açıdan değerlendirilmesini kolaylaştırmak adına iki örnek vaka da sunulmuştur.

Anahtar kelimeler: Üç ebeveynli bebek, mitokondriyal hastalıklar, mitokondri bağışı, genetik müdahale

Tam Metin:

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Referanslar


Kaynaklar:

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Ember, Melvin; Ember, Carol R., eds. (2004). Encyclopedia of Medical Anthropology: Health and Illness in the World's Cultures. 1. Cultures. New York: Kluwer Academic/Plenum Publishers. ISBN 0-306-47754-8

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M. Yamada et al. Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes. Cell Stem Cell. Published online May 19, 2016. doi: 10.1016/j.stem.2016.04.001.

L.A. Hyslop et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature. Published online June 8, 2016. doi: 10.1038/nature18303.

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Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases; Board on Health Sciences Policy; Institute of Medicine (2016). Claiborne, Anne; English, Rebecca; Kahn, Jeffrey, eds. Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations. National Academies Press. ISBN 978-0-309-38870-2

Sara Reardon. ‘Three-parent baby’ claim raises hopes — and ethical concerns. Nature doi:10.1038/nature.2016.20698

J. Zhang, H. Liu, S. Luo, A. Chavez-Badiola, Z. Liu, m. yang, S. Munne, M. Konstantinidis, D. Wells, T. Huang First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome DOI: http://dx.doi.org/10.1016/j.fertnstert.2016.08.004

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